D-Leu7-Triptorelin (CAS 321709-37-9) | Peptide Impurity Standard by Pharmaffiliates

D-Leu7-Triptorelin (CAS 321709-37-9) | Peptide Impurity Standard by Pharmaffiliates

D-Leu7-Triptorelin, identified by CAS number 321709-37-9, is a synthetic peptide categorized as an in-house impurity and research-grade reference material. It is structurally related to the well-known GnRH analogue Triptorelin, a peptide used in hormonal and oncology research. Unlike the parent compound, D-Leu7-Triptorelin is primarily intended for laboratory, analytical, and reference purposes rather than therapeutic use.

Chemical Profile and Specifications

Chemical Name: Glycinamide, 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-tryptophyl-D-leucyl-L-arginyl-L-prolyl
Molecular Formula: C₆₄H₈₂N₁₈O₁₃
Molecular Weight: 1311.47 g/mol
Product Code: PA PEP 003537
Category: Peptides / Reference Standards
Storage Condition: 2-8 °C (Refrigerator)
Shipping Condition: Ambient

These precise attributes help researchers and analytical laboratories maintain consistency in peptide testing and ensure traceability during experimental or quality control processes.

Scientific Background

Triptorelin and its analogues, including D-Leu7-Triptorelin, belong to the family of gonadotropin-releasing hormone (GnRH) analogues. These peptides play a key role in regulating the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH).

In research settings, D-Leu7-Triptorelin is significant for studying structure–activity relationships of peptides, impurity profiling, and peptide synthesis optimization. The substitution of D-leucine in the seventh position alters biological activity, making it valuable for comparative pharmacological and stability studies.




Applications and Research Use

D-Leu7-Triptorelin is not a drug but a reference or impurity standard. Its applications include:

  • Analytical Reference Standard: Used to verify the purity and composition of Triptorelin during manufacturing and testing.

  • Impurity Profiling: Helps detect and quantify related peptide impurities in pharmaceutical formulations.

  • Peptide Stability Studies: Supports research into degradation pathways and impurity formation during synthesis or storage.

  • Structural and Functional Research: Aids in understanding how amino acid substitutions influence GnRH analogue activity.

This compound is vital for laboratories focused on analytical chemistry, peptide synthesis, and pharmaceutical quality control.

Storage and Handling Recommendations

To maintain peptide integrity:

  • Store between 2-8 °C in a refrigerator.

  • Avoid multiple freeze-thaw cycles.

  • Use appropriate protective equipment when handling.

  • Dispose of waste as per local laboratory safety regulations.

Proper storage ensures the peptide’s structural stability and prevents degradation over time.

Regulatory and Compliance Information

As an impurity and research reference standard, D-Leu7-Triptorelin is not intended for human or animal use. It must be handled only in controlled laboratory environments by trained professionals.

Researchers and QC analysts should always review the Certificate of Analysis (COA) and Material Safety Data Sheet (MSDS) for batch-specific information, ensuring adherence to international compliance norms and laboratory safety requirements.

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