D-His2-Triptorelin (CAS 321709-34-6): Properties, Uses, and Reference Information

D-His2-Triptorelin (CAS number 321709-34-6) is a synthetic peptide compound belonging to the class of analytical reference standards and peptide impurities. It is primarily used in pharmaceutical research and quality control studies, especially for peptide-based drug development and analytical method validation.

This compound is recognized as an in-house reference material that helps in identifying and quantifying impurities related to Triptorelin, a well-known gonadotropin-releasing hormone (GnRH) analog used in cancer and hormone therapy research.

Chemical and Physical Properties


CAS Number321709-34-6
Chemical NameD-His2-Triptorelin
Molecular FormulaC₆₄H₈₂N₁₈O₁₃
Molecular Weight1311.47 g/mol
CategoryPeptide / Peptide Impurity
Storage ConditionsStore at 2–8 °C (refrigerated)
FormPeptide solid or lyophilized powder (as per analytical use)

The molecular structure of D-His2-Triptorelin is a modified analog of Triptorelin in which the second position of the peptide chain is substituted with D-Histidine. This modification slightly alters its physicochemical behavior, making it valuable for analytical comparison during impurity profiling.

D-His2-Triptorelin




Applications and Usage

  1. Impurity Profiling:
    D-His2-Triptorelin serves as a reference impurity standard used to detect, identify, and quantify related substances that may form during peptide synthesis or storage.

  2. Analytical Method Validation:
    It is used for validating chromatographic and spectrometric techniques such as HPLC, UPLC, and LC-MS in peptide research laboratories.

  3. Quality Control and Research:
    The compound assists pharmaceutical manufacturers and quality control units in maintaining the purity and safety of peptide formulations, ensuring they meet regulatory specifications.

  4. Comparative Studies:
    Researchers employ D-His2-Triptorelin to study structural and stability differences between analog peptides, supporting innovation in peptide synthesis and formulation design.

Storage and Handling Recommendations

  • Store in tightly sealed vials at 2–8 °C to maintain integrity.

  • Avoid exposure to moisture and light, as peptides are sensitive to environmental factors.

  • Use freshly prepared solutions for analytical work.

  • Reconstitute under sterile, low-temperature conditions using suitable solvents like water or buffer systems.

Following these precautions ensures reliable analytical results and preserves compound stability.

Quality Assurance and Certification

D-His2-Triptorelin is typically supplied with comprehensive documentation, including:

  • Certificate of Analysis (COA)

  • Material Safety Data Sheet (MSDS)

  • Purity Profile and Spectral Data

These documents verify the compound’s identity, purity, and compliance with analytical standards, making it suitable for regulated environments such as pharmaceutical R&D and QA/QC laboratories.

Key Advantages

  • High-purity peptide impurity reference

  • Supports FDA-aligned analytical validation

  • Enhances accuracy in impurity profiling

  • Stable under recommended storage conditions

  • Essential for peptide drug development and quality control


D-His2-Triptorelin (CAS 321709-34-6) is a benchmark peptide impurity standard that plays a critical role in pharmaceutical research, analytical testing, and peptide synthesis validation. Its high stability, defined purity, and analytical reliability make it a preferred choice for laboratories aiming to maintain precise quality standards in peptide drug development.

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