10-Bromo-5H-dibenzo[b,f]azepine-5-carbonyl Chloride: A Key Pharmaceutical Intermediate

10-Bromo-5H-dibenzo[b,f]azepine-5-carbonyl Chloride

10-Bromo-5H-dibenzo[b,f]azepine-5-carbonyl Chloride (CAS No. 143667-53-2) is a specialized chemical intermediate supplied by Pharmaffiliates for use in pharmaceutical research, development, and analytical applications. This compound is primarily utilized in the synthesis of complex molecules and impurity profiling within regulated pharmaceutical environments.

Chemical Profile

  • Chemical Name: 10-Bromo-5H-dibenzo[b,f]azepine-5-carbonyl Chloride

  • CAS Number: 143667-53-2

  • Molecular Formula: C₁₅H₉BrClNO

  • Molecular Weight: 334.6 g/mol

  • Storage Conditions: Recommended storage at 2–8 °C

This compound belongs to the class of acid chlorides, known for their high reactivity and importance in organic synthesis. The dibenzazepine core structure is particularly significant in medicinal chemistry due to its presence in several central nervous system–related drug molecules.

Importance in Pharmaceutical Development

Acid chlorides such as 10-Bromo-5H-dibenzo[b,f]azepine-5-carbonyl Chloride are widely used as building blocks in pharmaceutical synthesis. Their reactive carbonyl chloride group enables efficient formation of amides and related derivatives, which are essential steps in drug development pipelines.

Key applications include:

  • Synthesis of advanced pharmaceutical intermediates

  • Impurity identification and characterization

  • Reference standard preparation

  • Medicinal chemistry research and development

The brominated dibenzazepine framework also supports structure–activity relationship (SAR) studies, enabling researchers to explore molecular modifications and their pharmacological impact.

Role in Quality Control and Regulatory Studies

In regulated pharmaceutical manufacturing, impurity profiling and stability testing are critical. This compound supports:

  • Analytical method development

  • Validation studies

  • Regulatory submissions requiring impurity traceability

By providing high-quality intermediates and standards, Pharmaffiliates contributes to compliance with global regulatory expectations and quality benchmarks.

Handling and Safety Considerations

As an acid chloride, this compound is typically reactive and moisture-sensitive. Appropriate laboratory safety measures should be followed, including controlled handling conditions, use of personal protective equipment, and proper storage to preserve chemical integrity.

So,

10-Bromo-5H-dibenzo[b,f]azepine-5-carbonyl Chloride is a valuable pharmaceutical intermediate supporting research, synthesis, and analytical applications. Its role in medicinal chemistry, impurity profiling, and pharmaceutical quality control highlights its importance for companies focused on innovation, compliance, and scientific excellence.

Comments

Post a Comment

Popular posts from this blog

D-Leu7-Triptorelin (CAS 321709-37-9) | Peptide Impurity Standard by Pharmaffiliates

Image
D-Leu7-Triptorelin (CAS 321709-37-9) | Peptide Impurity Standard by Pharmaffiliates D-Leu7-Triptorelin, identified by CAS number 321709-37-9 , is a synthetic peptide categorized as an in-house impurity and research-grade reference material. It is structurally related to the well-known GnRH analogue Triptorelin , a peptide used in hormonal and oncology research. Unlike the parent compound, D-Leu7-Triptorelin is primarily intended for laboratory, analytical, and reference purposes rather than therapeutic use. Chemical Profile and Specifications Chemical Name: Glycinamide, 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-tryptophyl-D-leucyl-L-arginyl-L-prolyl Molecular Formula: C₆₄H₈₂N₁₈O₁₃ Molecular Weight: 1311.47 g/mol Product Code: PA PEP 003537 Category: Peptides / Reference Standards Storage Condition: 2-8 °C (Refrigerator) Shipping Condition: Ambient These precise attributes help researchers and analytical laboratories maintain consistency in peptide test...
Read more

CAS 2857963-60-9: Premium Peptide Reference Standard for Advanced Research & QC

Image
CAS 2857963-60-9: Premium Peptide Reference Standard for Advanced Research & QC CAS 2857963-60-9, also known as 3,6,9,12,15,18,21,24,27,30-Decamethyl-4,7,10,13,16,19,22,25,28,31-decaoxo-3,6,9,12,15,18,21,24,27,30-decaazadotriacontanoic acid , represents a highly specialized peptide-based reference compound widely utilized in pharmaceutical research, analytical testing, and peptide formulation development. Due to its extended chain length and multiple carbonyl-amide functional groups, this molecule plays a key role in validating purification protocols, analyzing peptide impurities, and studying long-chain peptide analogs. This compound is especially valuable in R&D facilities, peptide synthesis laboratories, CROs, CDMOs, and regulated pharmaceutical environments , where accuracy, traceability, and certified quality standards are critical. Chemical Profile & Structure CAS Number 2857963-60-9 Chemical Nature Long-chain poly-peptide analog Functional Groups Carbonyl, amide...
Read more

Exploring D-Leu-4-OB3 (CAS 289056-32-2): A Key Research Peptide with Scientific Potential

Image
Exploring D-Leu-4-OB3 (CAS 289056-32-2): A Key Research Peptide with Scientific Potential Pharmaffiliates Private Limited lists D-Leu-4-OB3 under catalogue number PA PEP 003427 , with the CAS number 289056-32-2 . This compound falls under the “Peptides” category on the Pharmaffiliates website and is offered primarily for research purposes . The chemical name of the compound is: L-Threonine, L-seryl-L-cysteinyl-L-seryl-D-leucyl-L-prolyl-L-glutaminyl-; L-seryl-L-cysteinyl-L-seryl-D-leucyl-L-prolyl-L-glutaminyl-L-threonine; Mus musculus [D-Leu-4]-OB3 peptide; Mouse [D-Leu-4]-OB3. Its molecular formula is C₂₉H₅₀N₈O₁₂S , with a molecular weight of 734.82 g/mol . The product page specifies storage conditions of 2-8 °C with ambient shipping . These details ensure that researchers are aware of both the storage and handling requirements of the compound. Composition and Structure D-Leu-4-OB3 is a synthetic research peptide that contains both L- and D-amino acids . The “D-Leu” part of t...
Read more