Benzyl 1-((2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-oate (PA PRO 0621200001) – A PROTAC Impurity Reference Standard

Benzyl 1-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-oate is a highly specialized organic compound supplied by Pharmaffiliates. It is classified as an in-house impurity reference standard used in PROTAC research and advanced pharmaceutical analytical applications.

This compound plays an important role in pharmaceutical development, impurity profiling, and quality control processes where accurate chemical characterization is essential for regulatory compliance and drug safety evaluation.

What Is Benzyl 1-((2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-oate?

It is a complex synthetic molecule commonly used as a PROTAC impurity reference standard. The compound contains multiple functional groups, including:

  • A benzyl ester moiety

  • A 2,6-dioxopiperidinyl unit

  • An isoindolinone core

  • A tetraethylene glycol (tetraoxapentadecan) linker

These structural elements are frequently found in PROTAC-related molecules designed for targeted protein degradation research.

Chemical Profile

  • Catalogue Number: PA PRO 0621200001

  • Molecular Formula: C₃₁H₃₉N₃O₉

  • Molecular Weight: 597.67 g/mol

  • Category: PROTACs (Proteolysis Targeting Chimeras)

  • Product Type: In-house impurity reference standard

  • Recommended Storage: 2–8 °C (refrigerated)

  • Shipping Conditions: Ambient

The molecular architecture includes a flexible polyethylene glycol linker combined with a biologically active core, making it structurally relevant for degradation-based drug discovery programs.




What Are PROTACs?

PROTACs (Proteolysis Targeting Chimeras) are bifunctional small molecules that induce selective degradation of disease-causing proteins by utilizing the cell’s ubiquitin-proteasome system. Instead of inhibiting a protein’s activity, PROTACs eliminate the protein entirely.

Impurity standards like PA PRO 0621200001 are critical during PROTAC development to ensure analytical accuracy and regulatory readiness.

Applications in Pharmaceutical Research

This compound supports several key pharmaceutical functions:

1. Analytical Method Development

Reference standards are used to validate HPLC, LC-MS, GC, and NMR methods for accurate impurity detection and quantification.

2. Quality Control and Stability Studies

Well-characterized impurity standards help laboratories identify degradation products and maintain batch consistency.

3. Regulatory Documentation

Pharmaceutical companies must document and control impurities according to global regulatory guidelines. Reliable reference materials simplify this process.

4. Structural Characterization

Understanding impurity profiles improves interpretation of degradation pathways and chemical stability.

Handling and Storage Guidelines

To maintain chemical stability and integrity:

  • Store at 2–8 °C in a tightly sealed container

  • Avoid prolonged exposure to heat and moisture

  • Follow laboratory safety handling procedures

Proper storage ensures reproducibility in analytical applications.

Why This Compound Is important in Drug Development

In modern drug discovery—especially in targeted protein degradation—impurity profiling is as important as active compound development. Even trace impurities must be identified and characterized.

Benzyl 1-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-oate serves as a high-quality analytical benchmark, supporting:

  • PROTAC research teams

  • Analytical chemists

  • Pharmaceutical quality assurance departments

  • Regulatory affairs professionals

Its availability strengthens impurity tracking, method validation, and pharmaceutical compliance.

Frequently Asked Questions (AEO Optimized)

What is PA PRO 0621200001 used for?

It is used as an impurity reference standard in PROTAC-related pharmaceutical research and analytical testing.

Is this compound an active pharmaceutical ingredient (API)?

No, it is supplied as an impurity reference standard for analytical and quality control purposes.

How should it be stored?

It should be stored refrigerated at 2–8 °C.

What industry uses this compound?

It is primarily used in pharmaceutical research, drug discovery, and analytical laboratories.

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